Publications - May 2021

Preprint and peer-reviewed publications from RECOVER’s studies

Therapeutic Anticoagulation in Non-Critically Ill Patients with Covid-19 (Lawler et al. 2021)

 Thrombo-inflammation may contribute to morbidity and mortality in Covid-19. We hypothesized that therapeutic-dose anticoagulation may improve outcomes in non-critically ill patients hospitalized for Covid-19. Methods In an open-label adaptive multiplatform randomized controlled trial, non-critically ill patients hospitalized for Covid-19, defined by the absence of critical care-level organ support at enrollment, were randomized to a pragmatic strategy of therapeutic-dose anticoagulation with heparin or usual care pharmacological thromboprophylaxis. The primary outcome combined survival to hospital discharge and days free of organ support through 21 days, which was evaluated with Bayesian statistical models according to baseline D-dimer.

Read article

Estimating infectiousness throughout SARS-CoV-2 infection course (Jones et al. 2020)

As children are under-represented in current studies aiming to analyse transmission of SARS-coronavirus 2 (SARS-CoV-2), their contribution to transmission is unclear. Considerable uncertainty remains regarding the influence of different contact behaviour in children versus adults, and the extent to which children can act as sources of infection in general.

We conclude that a considerable percentage of infected people in all age groups, including those who are pre- or mild-symptomatic, carry viral loads likely to represent infectivity. Based on these results and uncertainty about the remaining incidence, we recommend caution and careful monitoring during gradual lifting of non-pharmaceutical interventions. In  particular, there is little evidence from the present study to support suggestions that children may not be as infectious as adults.

Read preprint article

Transmission of SARS-CoV-2 within households: a prospective cohort study in the Netherlands and Belgium - Interim results (de Hoog et al. 2021)

Household transmission studies are useful to obtain granular data on SARS-CoV-2 transmission dynamics and to gain insight into the main determinants. In this interim report we investigated secondary attack rates (SAR) by household and subject characteristics in the Netherlands and Belgium.

Read article