Publications - April 2021
Preprint and peer-reviewed publications from RECOVER’s studies
The aim of this study was to analyse the impact of endemic seasonal coronavirus infection on SARS-CoV-2 infection in children by investigating in depth the typology of respective humoral responses, based on a luciferase immunoprecipitation system (LIPS) assay targeting the spike (S) and the nucleoprotein (N) of SARS-CoV-2 and the four seasonal coronaviruses. We measured if prior infections with HCoV, evidenced by antibody responses, modulate the risk of SARS-CoV-2 infection by analysing the frequency and the level of response in SARS-CoV-2-positive children as compared with SARS-CoV-2-negative matched controls. We also analysed humoral responses against SARS-CoV-2 and seasonal HCoV in patients with MIS regarding antibody targets.
A retrospective closed cohort study among pupils, their parents and siblings, as well as teachers and non-teaching staff of a high-school located in Oise, France to estimate by antibody detection the infection attack rate of SARS-CoV-2 infection in a community affected by COVID-19 (Fontanet et al. 2020).
Facing B.1.1.7 variant, social distancing was strengthened in France in January 2021. Using a 2-strain mathematical model calibrated on genomic surveillance, we estimated that social distancing allowed hospitalizations to plateau, by decreasing transmission of the historical strain while B.1.1.7 continued to grow. Variant dominance is expected by the end of February-early March in France, with large geographical heterogeneity. Without strengthened social distancing, a rapid surge of hospitalizations is expected in the next weeks.