Publications - April 2021
Preprint and peer-reviewed publications from RECOVER’s studies
The aim of this study was to analyse the impact of endemic seasonal coronavirus infection on SARS-CoV-2 infection in children by investigating in depth the typology of respective humoral responses, based on a luciferase immunoprecipitation system (LIPS) assay targeting the spike (S) and the nucleoprotein (N) of SARS-CoV-2 and the four seasonal coronaviruses. We measured if prior infections with HCoV, evidenced by antibody responses, modulate the risk of SARS-CoV-2 infection by analysing the frequency and the level of response in SARS-CoV-2-positive children as compared with SARS-CoV-2-negative matched controls. We also analysed humoral responses against SARS-CoV-2 and seasonal HCoV in patients with MIS regarding antibody targets.
Household transmission studies are useful to obtain granular data on SARS-CoV-2 transmission dynamics and to gain insight into the main determinants. In this interim report we investigated secondary attack rates (SAR) by household and subject characteristics in the Netherlands and Belgium.