Publications - March 2021

Preprint and peer-reviewed publications from RECOVER’s studies

Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics (Schroeder et al. 2021)

The COVID-19 agent, SARS-CoV-2, is conspecific with SARS-CoV, the causal agent of the severe acute respiratory syndrome epidemic in 2002–03. Although the viruses share a completely homologous repertoire of proteins and use the same cellular entry receptor, their transmission efficiencies and pathogenetic traits differ. We aimed to compare interferon antagonism by SARS-CoV and SARS-CoV-2.

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Clinical evaluation of the Roche/SD Biosensor rapid antigen test with symptomatic, non-hospitalized patients in a municipal health service drive-through testing site (Iglὁi et al. 2020)

Rapid detection of infectious individuals is essential in stopping the further spread of SARS-CoV-2.
Although rapid antigen test is not as sensitive as the gold standard RT-PCR, the time to result is decreased
by day(s), strengthening the effectiveness of contact tracing. 

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Model-based evaluation of school- and non-school-related measures to control the COVID-19 pandemic (Rozhnova et al. 2021)

The role of school-based contacts in the epidemiology of SARS-CoV-2 is incompletely understood. We use an age-structured transmission model fitted to age-specific seroprevalence and hospital admission data to assess the effects of school-based measures at different time points during the COVID-19 pandemic in the Netherlands. Our analyses suggest that the impact of measures reducing school-based contacts depends on the remaining opportunities to reduce non-school-based contacts.

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Experiences and needs of persons living with a household member infected with SARS-CoV-2: A mixed method study (Verberk et al. 2021)

Households are important sites for transmission of SARS-CoV-2 and preventive measures are recommended. This study aimed to 1) investigate the impact of living with a person infected with SARS-CoV-2; 2) understand how household members implemented infection control recommendations in their home; and 3) identify the information and support needs of household members.

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