Publications - July 2021

Preprint and peer-reviewed publications from RECOVER’s studies

Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial (Arabi et al. 2021)

This study investigates the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with COVID-19. Critically ill adults with COVID-19 were randomized to receive lopinavir-ritonavir, hydroxychloroquine, combination therapy of lopinavir-ritonavir and hydroxychloroquine or no antiviral therapy (control). The results show that, among critically ill patients with COVID-19, lopinavir-ritonavir, hydroxychloroquine, or combination therapy worsened outcomes compared to no antiviral therapy.

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ISARIC Clinical Data Report issued: 14 July 2021 (ISARIC Clinical Characterisation Group et al. 2021)

ISARIC (International Severe Acute Respiratory and emerging Infections Consortium) partnerships and outbreak preparedness initiatives enabled the rapid launch of standardised clinical data collection on COVID-19 in Jan 2020. Extensive global uptake of this resource has resulted in a large, standardised collection of comprehensive clinical data from hundreds of sites across dozens of countries. Data are analysed regularly and reported publicly to inform patient care and public health response. This report, our 15th report, is a part of a series and includes the results of data analysis for data captured before 26 May 2021. The report marks a significant milestone – the submission of clinical data from over half a million individuals hospitalised with COVID-19. 

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Primary care for patients with respiratory tract infection before and early on in the COVID-19 pandemic: an observational study in 16 European countries (van der Velden et al. 2021)

This study describes primary health care (consultation characteristics and management) for patients contacting their general practitioner (GP) with a respiratory tract infection (RTI) early on in the COVID-19 pandemic in contrasting European countries, with comparison to prepandemic findings.

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Transformation of primary care during the COVID-19 pandemic: experiences of healthcare professionals in eight European countries (Wanat et al. 2021)

Primary care has a crucial role in responding to the COVID-19 pandemic as the first point of patient care and gatekeeper to secondary care. Qualitative studies exploring the experiences of healthcare professionals during the COVID-19 pandemic have mainly focused on secondary care. This study aims to understand the experiences of European PCPs working during the first peak of the COVID-19 pandemic.

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