Publications - April 2022
Preprint and peer-reviewed publications from RECOVER’s studies
Recombination is a crucial process in the evolution of many organisms. Although the evolutionary
reasons behind its occurrence in RNA viruses are debated, this phenomenon has been associated with
major epidemiological events such as virus host range expansion, antigenic shift or variation in virulence
1,2, and this process occurs frequently in positive strand RNA viruses such as coronaviruses.
Viral evolution towards resistance against sotrovimab can explain treatment failure in most
immunocompromised patients and these patients can remain infectious after treatment. Therefore,
ISARIC (International Severe Acute Respiratory and emerging Infections Consortium) partnerships and outbreak preparedness initiatives enabled the rapid launch of standardised clinical data collection on COVID-19 in Jan 2020. Extensive global participation has resulted in a large, standardised collection of comprehensive clinical data from hundreds of sites across dozens of countries. Data are analysed regularly and reported publicly to inform patient care and public health response. This report, our 17th report, is a part of a series published over the past 2 years.