ISARIC published new COVID-19 Clinical Data Report

14 January 2022

RECOVER’s partner ISARIC has recently published a report describing the clinical presentation, treatment and outcome of a cohort of over 700,000 patients with COVID-19, hospitalised between January 2020 and September 2021 in 64 countries throughout the world. This has been possible thanks to 1669 institutions and their clinical teams contributing to ISARIC.

ISARIC (International Severe Acute Respiratory and emerging Infections Consortium) partnerships and outbreak preparedness initiatives enabled the rapid launch of standardised clinical data collection on COVID-19 in January 2020. Extensive global uptake of this resource has resulted in a large, standardised collection of comprehensive clinical data from hundreds of sites across dozens of countries. Data are analysed regularly and reported publicly to inform patient care and public health response. This report, the 16th ISARIC’s report, is a part of a series.

The comprehensive analyses detailed in this report includes hospitalised individuals of all ages for whom data collection occurred between 30 January 2020 and up to and including 21 September 2021, AND who have laboratory-confirmed SARS-COV-2 infection or clinically diagnosed COVID-19.

COVID-19 has tested the effectiveness of ISARIC’s operating model: a global, open-source, collaborative approach set up 10 years ago to prevent illness and deaths from infectious disease outbreaks.

In January 2020, ISARIC launched its COVID-19 Clinical Characterisation Protocol (CCP) and Case Report Form (CRF) as well as a free data management platform for researchers to upload their clinical data, globally. The ISARIC COVID-19 CCP database was open and publicly accessible from late January 2020, when less than a thousand COVID19 cases had been reported globally; by mid-February 2020, the first patient record was successfully uploaded the platform; by mid-March 2020, the platform had ten thousand records. Now, 22 months into the pandemic, with more than half-a-million records, the ISARIC clinical data platform has grown to become the largest international individual patient dataset of COVID-19 hospitalised cases.

ISARIC is a model of global peer-to-peer collaboration, with contributions by 1669 sites in 64 countries, with similar representations of patients from high-income and low- and middle-income countries.

This report describes the features of COVID-19 patients in the entire cohort, made from cases accrued over 22 months with different contributions from various countries. Everyone can trace the evolution over time of the database through 15 previous versions of this report . In addition, specific questions regarding clinical presentations, risks factors for outcomes, and trends are addressed through ad-hoc analyses.

Read the full report here.

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